While the 49ers couldn't rest every starter, many were pulled by halftime. Defensive end Clenin Ferrell who started the game at edge rusher opposite Nick Bosa, suffered a knee injury in the 49ers second defensive series. He was carted to the locker room and quickly declared out for the remainder of the game. As Ferrell cleared up after the game, the decision to rule him out was precautionary.
The only other injury suffered in the game was a wrist injury to safety Tayler Hawkins. Hawkins is signed to the 49ers practice squad but was a temporary elevation to play in Week 18. He recorded four tackles, one pass defended, and an interception before exiting the game late.
Linebacker Dre Greenlaw (achilles tendonitis) and tight end George Kittle (back spasm) who went through pre-game warm ups and were active to play, were both held out as a precaution.