With a win against the New York Giants on "Thursday Night Football" (5:15 PM PT, Prime Video), Purdy will improve to 8-0 in his career as a starter, marking the third-most consecutive wins by a quarterback to begin his career since 1970. Only Ben Roethlisberger (15 consecutive wins to begin his career) and Mike Tomczak (10) had longer streaks.
The quarterbacks with the most consecutive wins to begin their careers since 1970:
| Player | Team(s) | Season(s) | WINS |
| Ben Roethlisberger | Steelers | 2004-05 | 15 |
| Mike Tomczak | Bears | 1986-87 | 10 |
| Dieter Brock | Rams | 1985 | 7 |
| Daunte Culpepper | Vikings | 2000 | 7 |
| Jimmy Garoppolo | Patriots, 49ers | 2016-17 | 7 |
| Brock Purdy | 49ers | 2022-23 | 7 |
Running back Christian McCaffrey leads the NFL with 268 rushing yards entering Week 3 and has recorded at least 115 rushing yards and a rushing touchdown in each of San Francisco's first two games. McCaffrey can become the third player ever to record 115 rushing yards and a rushing touchdown in each of his team's first three games of a season, joining Pro Football Hall of Famers Jim Brown (1958) and O.J. Simpson (1975).
Since Week 13 of the 2022 season, McCaffrey has scored a touchdown in 11 straight games, including the postseason. With a touchdown on Thursday night, he will become the fifth player since 1990 to record a touchdown in 12 consecutive games, including the postseason.
The players with the most consecutive games with a touchdown, including the postseason, since 1990:
| Player | Team | Games (Dates) |
| Emmitt Smith | Cowboys | 14 (Oct. 8, 1995 – Jan. 28, 1996) |
| Arian Foster | Texans | 13 (Dec. 18, 2011 – Nov. 11, 2012) |
| Emmitt Smith | Cowboys | 13 (Nov. 7, 1994 – Sept. 24, 1995) |
| LaDainian Tomlinson | Chargers | 12 (Oct. 3 – Dec. 26, 2004) |
| Christian McCaffrey | 49ers | 11 (Dec. 4, 2022 – current) |
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