Cam Inman of Bay Area News Group provided the following list of players changing numbers and the new digits they will wear moving forward.
- No. 3, wide receiver Ray-Ray McCloud
- No. 6, wide receiver Danny Gray
- No. 7, cornerback Charvarius Ward
- No. 13, quarterback Brock Purdy
- No. 24, running back Jordan Mason
- No. 26, cornerback Samuel Womack III
- No. 30, safety Talanoa Hufanga
- No. 32, running back Tyrion Davis-Price
- No. 48, linebacker Oren Burks
- No. 61, guard Blake Hance
- No. 63, guard Nick Zakelj
- No. 74, guard Spencer Burford
- No. 92, defensive end Kerry Hyder Jr.
- No. 94, defensive end Charles Omenihu
- No. 95, defensive end Drake Jackson
- No. 98, defensive tackle Hassan Ridgeway
Below are the numbers of the players on the 49ers' newly-created practice squad. Wide receiver Tay Martin takes over Purdy's former number.
- No. 14, wide receiver Tay Martin
- No. 17, wide receiver Malik Turner
- No. 31, safety Tashaun Gipson Sr.
- No. 40, linebacker Marcelino McCrary-Ball
- No. 41, safety Tayler Hawkins
- No. 43, defensive back Qwuantrezz Knight
- No. 53, defensive end Kemoko Turay
- No. 55, defensive tackle Akeem Spence
- No. 58, defensive lineman Alex Barrett
- No. 62, guard Jason Poe
- No. 66, center Keaton Sutherland
- No. 77, offensive tackle Alfredo Gutierrez
- No. 83, wide receiver Willie Snead IV