As usual, the San Francisco 49ers will meet each NFC West team twice. On May 4, the NFL revealed that the 49ers will travel to Mexico City on November 21 to face the Arizona Cardinals at Estadio Azteca—a Week 11 primetime matchup on ESPN's Monday Night Football.
The 49ers will face the third-place teams in the NFC East, NFC North, and AFC East. The team is also slated to play the entire NFC South and AFC West.
NFL Kickoff Weekend will begin on Thursday, September 8, culminating with Super Bowl LVII on February 12, 2023, at State Farm Stadium in Glendale, Arizona.
Below are the dates and times (if known) for 49ers games during the upcoming season and who reported each matchup. Once the full schedule is released, I will post it separately.
The full schedule has been released: Complete 2022 San Francisco 49ers Schedule Revealed
Known Matchup Dates/Times
- Week 1: at Bears (per Danny Parkins)
- Week 2: Seahawks (per NFL Network)
- Week 3: at Broncos (SNF, unconfirmed)
- Week 4: Rams (unconfirmed)
- Week 5: at Panthers (unconfirmed)
- Week 6: at Falcons (unconfirmed)
- Week 7: Chiefs (unconfirmed)
- Week 8: at Rams (unconfirmed)
- Week 9: BYE
- Week 10: Chargers (SNF, per Mike Kaye)
- Week 11: at Cardinals in Mexico City (per NFL)
- Week 12: Saints (per Dov Kleiman)
- Week 13: Dolphins (unconfirmed)
- Week 14: Buccaneers (unconfirmed)
- Week 15: at Seahawks (TNF, unconfirmed)
- Week 16: Commanders (Christmas Eve, per Mike Kaye)
- Week 17: at Raiders (unconfirmed)
- Week 18: Cardinals (unconfirmed)
Note: "Unconfirmed" listings are based on what I am hearing and should be treated as a rumor until an official member of the media reports it.
Home/Away Opponents
Below are all of San Francisco's home and away opponents for the 2022 season.
HOME (9 games)
- Arizona Cardinals
- Kansas City Chiefs
- Los Angeles Chargers
- Los Angeles Rams
- Miami Dolphins
- New Orleans Saints
- Seattle Seahawks
- Tampa Bay Buccaneers
- Washington Commanders
AWAY (8 games)
- Arizona Cardinals
- Atlanta Falcons
- Carolina Panthers
- Chicago Bears
- Denver Broncos
- Los Angeles Rams
- Las Vegas Raiders
- Seattle Seahawks
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