Activated from injured reserve:
- RB Trenton Cannon
Activated from the practice squad (standard elevations):
- LB Mark Nzeocha
- QB Nate Sudfeld
Waived:
- WR River Cracraft
Cannon suffered a concussion on December 5, 2021, against the Seattle Seahawks and was placed on injured reserve on December 11, 2021. San Francisco opened his practice window on January 12.
The winner of Sunday's game will represent the NFC in the playoffs. San Francisco is coming off a 13-10 win over the Green Bay Packers in the Divisional Playoff round while Los Angeles knocked off the Tampa Bay Buccaneers 30-27. The Rams are a 3.5-point favorite over the 49ers.
The two teams will announce their inactive players 90 minutes ahead of kickoff.
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