On Wednesday, head coach Kyle Shanahan said he is "pretty optimistic" Garoppolo would be available for Sunday's home game against the Indianapolis Colts. However, he was less sure about the status of his rookie quarterback and Garoppolo's backup, Trey Lance.
"He might have a chance at the end of the week, but I'd be surprised if he's not ready to go until next week," Shanahan said of Lance.
Lance has not practiced this week and was not on the practice field with his teammates at the start of today's session.
Garoppolo is returning from a calf injury that forced him to miss Week 5's contest against the Arizona Cardinals. Lance started in his place for that game but emerged with a knee sprain.
It's worth noting that reporters didn't see left tackle Trent Williams on the practice field for the second consecutive day. He is dealing with elbow and ankle injuries. That would be a significant loss for the 49ers if they were forced to enter Sunday's game without their best offensive lineman.
Defensive tackle Javon Kinlaw also missed his second consecutive practice as he deals with the knee injury that has limited him all season.
This weekend against the Colts, San Francisco looks to snap a three-game losing streak that has dropped the team to 2-3 on the season.
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