After two consecutive losses at home, the San Francisco 49ers hope to turn things around on the road against the NFC West-leading Arizona Cardinals. The Niners look to improve to 33-27 overall against the division foe. The Bay Area squad has won three of the past four matchups between the two teams. The 49ers have also won each of the previous two meetings at State Farm Stadium.

San Francisco is coming off a 21-28 loss to the Seattle Seahawks at Levi's Stadium. Arizona is undefeated and coming off a 37-20 victory over the Los Angeles Rams.


Wide receiver Deebo Samuel finished the game with eight receptions for 156 yards and two touchdowns, marking his first career game with multiple touchdown receptions. Rookie quarterback Trey Lance started the second half in place of an injured Jimmy Garoppolo, connecting on nine of 18 passing attempts for 157 yards and two touchdowns while adding seven rushing attempts for 41 yards. Running back Trey Sermon led the team with 89 rushing yards on 19 carries.

San Francisco's defense held Seattle to 234 total net yards on the day, including 129 net passing yards. The 49ers pass rush forced three sacks of Seahawks quarterback Russell Wilson and hope to limit Cardinals quarterback Kyler Murray this weekend.

Here is everything you need to know to follow the upcoming game.

When does the game start?

Sunday, October 10 at 1:25 p.m. PT


Where is the game being played?

State Farm Stadium in Glendale, Arizona

Who are the coaches?

The 49ers' head coach is Kyle Shanahan. The Cardinals' head coach is Kliff Kingsbury.

What channel is the game on?


Network: FOX
Play-By-Play: Kevin Kugler
Color Analyst: Mark Sanchez
Sideline Reporter: Laura Okmin

NFL Sunday Ticket subscribers can find the game on channel 715.

What areas will receive the broadcast?

For those without NFL Sunday Ticket, the broadcast will be viewable within the markets designated below.

Coverage map courtesy of 506sports.com


Where can I stream the game?


NFL Sunday Ticket subscribers can stream the game using the service's official mobile app. NFL Game Pass subscribers can stream the game in its entirety once the matchup has been completed.

Bay Area fans can stream the game through the official 49ers app or at 49ers.com.

Where can I listen to the radio broadcast?

Bay Area fans can listen on KGO 810 AM and KSAN 107.7 FM The Bone, where Greg Papa and Tim Ryan will call the game.

Jesús Zárate and Carlos Yustis will call the game in Spanish. That broadcast can be listened to at 49ers.com/news/Espanol.


Arizona fans can listen on Arizona Sports 98.7 FM, where Dave Pasch and Ron Wolfley will call the game.

NFL Game Pass subscribers will be able to listen to the game through that service.

Live updates

There will be a game-day article here at 49ers Webzone providing live updates starting during pre-game action.

Game discussion


Fans can discuss the game within our Niner Talk forum.

How has this series played out historically?

Matchups: 59
Series Record: 49ers lead series 32-27
49ers Home Record vs. Cardinals: 49ers lead series 18-13
49ers Away Record vs. Cardinals: Series is tied 14-14
First Meeting: 11/18/51, Cardinals win 27-21, at SF*
Last Meeting: 12/26/20, 49ers win 20-12, at Arz.
Current Streak: Won 1
Longest 49ers Win Streak: 5 – 3 times (Last 9/13/09 – 11/20/11)
Longest Cardinals Win Streak: 8 – (9/27/15 – 10/28/18)
Most 49ers Points: 56 (10/18/92): 49ers win 56-17, at SF
Most Cardinals Points: 34 – 2 times, (Last 9/10/06): Cardinals win 34-27, at Arz.
49ers Shutouts: None
Cardinals Shutouts: None
*Chicago Cardinals

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