Mitchell finished the game with 104 yards and a touchdown on 19 carries, entering the lineup after Raheem Mostert exited with a knee injury.
The other award nominees are quarterbacks Trevor Lawrence of the Jacksonville Jaguars and Mac Jones of the New England Patriots, wide receivers Ja'Marr Chase of the Cincinnati Bengals and DeVonta Smith of the Philadelphia Eagles, and cornerback Paulson Adebo of the New Orleans Saints.
Fans can click here to vote for the 49ers rookie through Friday.
San Francisco made Mitchell a sixth-round draft pick out of Louisiana, where he racked up 3,267 rushing yards, 41 rushing touchdowns, 597 receiving yards, and five receiving touchdowns through his four collegiate seasons.
More San Francisco 49ers News
-
49ers in Week 2 power rankings: San Francisco soars after big win over Rams
The San Francisco 49ers opened their 2026 NFL campaign with a statement win over a division rival. San Francisco traveled to Melbourne, Australia, and secured a convincing 27-7 win over the Los Angeles Rams. It was a significant win for the 49ers, who entered Week 1 as... -
49ers' Brock Purdy climbs QB rankings after win over Rams
NFL Media's Nick Shook sparked debate a week ago when the first installment of his 2026 quarterback rankings had San Francisco 49ers quarterback Brock Purdy listed at No. 15. Purdy made a statement in Week 1 against the Los Angeles Rams, leading the 49ers to a 27-7 win in... -
49ers Week 2 win over Dolphins produces historic stats and milestones
The San Francisco 49ers improved to 2-0 on the season after a 35-13 Week 2 win over the Miami Dolphins at Levi's Stadium in Santa Clara, California. Below are several statistics and notes from Sunday's game, which were provided by the 49ers Communications staff. With The... -
Kyle Shanahan shares 49ers updates one day after Week 2 win vs. Dolphins
San Francisco 49ers head coach Kyle Shanahan spoke with reporters during a conference call on Monday, one day after the team's 35-13 win over the Miami Dolphins. Here's everything he said. Transcript provided by the San Francisco 49ers Communications staff. Opening...