Head coach Kyle Shanahan announced on Friday that linebacker Dre Greenlaw is among the players who are ruled "out" for Sunday.
"Greenlaw had a calf strain," Shanahan said. "Complained of some calf tightness after practice yesterday. We got an MRI, saw it was strained, so he couldn't go."
San Francisco will also be without rookie defensive tackle Javon Kinlaw, veteran corner K'Waun Williams, and several others.
Tackle Trent Williams (elbow) and defensive end Jordan Willis (ankle) were placed on injured reserve.
Below are the official injury reports for the 49ers and Seahawks, which were provided by the 49ers Communications staff. Also included are Friday's practice participation reports.
San Francisco 49ers
Out
WR Brandon Aiyuk (ankle), DT Kevin Givens (not injury related), LB Dre Greenlaw (calf), DT Javon Kinlaw (knee), WR Deebo Samuel (hamstring), CB Richard Sherman (calf), CB K'Waun Williams (shin)
Questionable
S Tarvarius Moore (ankle), CB Emmanuel Moseley (hamstring), LB Mark Nzeocha (illness)
Seattle Seahawks
Out
RB DeeJay Dallas (ankle), CB Jayson Stanley (hamstring)
Questionable
RB Carlos Hyde (illness), G Mike Iupati (neck), TE Greg Olsen (foot), S Damarious Randall (foot, not injury related), T Brandon Shell (ankle, not injury related)
San Francisco 49ers Friday Practice
Did Not Participate In Practice
WR Brandon Aiyuk (ankle), DT Kevin Givens (not injury related), LB Dre Greenlaw (calf), DT Javon Kinlaw (knee), WR Deebo Samuel (hamstring), CB Richard Sherman (calf), CB K'Waun Williams (shin)
Limited Participation in Practice
S Tarvarius Moore (ankle), CB Emmanuel Moseley (hamstring), LB Mark Nzeocha (illness)
Full Participation in Practice
DE Dion Jordan (knee), T Justin Skule (knee), S Jimmie Ward (concussion), TE Charlie Woerner (not injury related)
Seattle Seahawks Friday Practice
Did Not Participate In Practice
RB DeeJay Dallas (ankle), RB Carlos Hyde (illness), G Mike Iupati (neck), CB Jayson Stanley (hamstring)
Limited Participation in Practice
TE Greg Olsen (foot), S Damarious Randall (foot, not injury related), T Brandon Shell (ankle, not injury related)
Full Participation in Practice
S Jamal Adams (hand), T Duane Brown (knee, not injury related), RB Chris Carson (foot), DT Bryan Mone (ankle), CB Ryan Neal (hip), RB Rashaad Penny (knee)
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