Jones was initially reported as "questionable" to return, but his status was later downgraded.
"He didn't come back, so they worried it possibly could be a high-ankle (sprain)," head coach Kyle Shanahan said after the game. "So, that's what we've got to look into. Obviously, we're hoping it's not."
The Bills beat the 49ers 34-24 at State Farm Stadium in Glendale, Arizona, and San Francisco fell to 5-7 on the season.
Note: Article updated with post-game information from Kyle Shanahan.
More San Francisco 49ers News
-
Vic Fangio: 49ers QBs Brock Purdy, Mac Jones have similar skill sets
The Philadelphia Eagles are preparing to host the San Francisco 49ers on Sunday in an NFC Wild Card playoff matchup. The two franchises have met just twice in the postseason, splitting those meetings with one win apiece. The 49ers enter the playoff game banged up, a familiar... -
49ers praise Mac Jones for keeping playoff hopes alive during Purdy's absence
The San Francisco 49ers understand they might not be in their current position without quarterback Mac Jones' contributions this season. When starter Brock Purdy missed time with a turf toe injury, Jones stepped in for eight games and delivered steady production, throwing for... -
NFL insider says 49ers QB Brock Purdy's shoulder stinger "not expected to keep him out next week"
The San Francisco 49ers looked bad in their bid for the number-one seed in the NFC Saturday night, falling 13-3 to the Seattle Seahawks. But things almost got much worse when QB Brock Purdy went down late in the game. It looked bad, and there was immediate concern about whether... -
49ers mailbag: More two TE sets with Jake Tonges? Will Trent Williams play Saturday? What are the rules for signing players from teams not in postseason?
This is a big week for the San Francisco 49ers as they prepare to host the Seattle Seahawks on Saturday night. The winner of the game will be crowned NFC West Champions and will have home-field advantage throughout the NFC playoffs. So it's a huge game. For the 49ers, it's...