Garoppolo left the game late in the third quarter with an ankle injury, while Kittle exited early in the fourth with a foot issue.
"They're both concerning," Rapoport said. "We'll see how serious Kittle's is but the fact that Jimmy Garoppolo continues to have issues with that ankle from the high-ankle sprain about a month or so ago, or a little more, is somewhat concerning for the 49ers.
"He left the game. Nick Mullens ended up cleaning up and finishing the game as Garoppolo headed to the locker room. But it really sounds like this is either a reaggravation of the ankle or just a sign that the ankle has just been hurting continuously. Clearly, he has not been quite the same player as he deals with this ankle injury."
Rapoport then went on to Kittle.
"He quickly headed to the locker room, had X-rays, which were negative, so that's good," Rapoport said. "(He's) going to have an MRI today just to determine how serious the sprain is and what the actual injury is. He missed a couple of games earlier in the season with an injury.
"He's extremely tough. If he can possibly get on the field, you know he will. But obviously, the MRI and test today loom very large for the Niners."
More San Francisco 49ers News
-
Why Ji'Ayir Brown's call to 49ers legends is concerning
In the NFL, sometimes the gap between a player's perception of himself and the reality of game film is wide. There are often too many people surrounding the player who tell him only what he wants to hear. Because of this, a young player can be easily convinced that he is better... -
49ers predictions: Analyst projects 2026 wins, stats for Purdy, McCaffrey, and more
ESPN analyst Mike Clay recently released his updated projections for the 2026 NFL season, including several key statistical forecasts for the San Francisco 49ers. Clay projects the NFC West to be one of the league's toughest divisions in 2026. He has the 49ers finishing third... -
49ers 2026 schedule: Here's what it looks like based on leaks
The NFL will officially unveil its full 272-game schedule for the 2026 season tonight at 5:00 p.m. PT. However, as is often the case ahead of the announcement, several matchups have already leaked—including what appears to be the San Francisco 49ers' complete 18-week... -
Full 2026 San Francisco 49ers Schedule Revealed
The NFL unveiled its full 272-game schedule for the 2026 regular season. The season kicks off on Wednesday, September 9, with the defending Super Bowl champion Seattle Seahawks hosting the opener at Lumen Field. The NFL season will conclude with Super Bowl LXI on February 14,...