Garoppolo left the game late in the third quarter with an ankle injury, while Kittle exited early in the fourth with a foot issue.
"They're both concerning," Rapoport said. "We'll see how serious Kittle's is but the fact that Jimmy Garoppolo continues to have issues with that ankle from the high-ankle sprain about a month or so ago, or a little more, is somewhat concerning for the 49ers.
"He left the game. Nick Mullens ended up cleaning up and finishing the game as Garoppolo headed to the locker room. But it really sounds like this is either a reaggravation of the ankle or just a sign that the ankle has just been hurting continuously. Clearly, he has not been quite the same player as he deals with this ankle injury."
Rapoport then went on to Kittle.
"He quickly headed to the locker room, had X-rays, which were negative, so that's good," Rapoport said. "(He's) going to have an MRI today just to determine how serious the sprain is and what the actual injury is. He missed a couple of games earlier in the season with an injury.
"He's extremely tough. If he can possibly get on the field, you know he will. But obviously, the MRI and test today loom very large for the Niners."
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