Jimmy Garoppolo left the game with an ankle injury after a sack late in the third quarter. The quarterback missed two games earlier this season with a high-ankle sprain.
"I know it was hurt, which I think we all saw when he didn't go back in on that one play," Shanahan told reporters. "He had a good week of practice throwing it, but high-ankle sprains linger, so you never know when it's going to affect you. I know he hurt it later in the game, or re-hurt it, and we'll wait until tomorrow to see how bad it is."
Tight end George Kittle left the game early in the fourth quarter and did not return. The team reported that he suffered a foot injury.
"Kittle, nothing was broken, at least on the X-rays," Shanahan said. "So, we've got to check MRIs and stuff tomorrow."
Shanahan added that he's hoping to get tight end Jordan Reed back in time for the 49ers' game against the Green Bay Packers in four days.
Tevin Coleman was activated off injured reserve on Saturday after suffering a knee injury during Week 2. The running back left the game with an injury to the same knee and did not return.
"Yeah, it was the same knee," Shanahan said. "He wanted to go back in. We tried, and he just couldn't. So, I don't know what the deal is for this week. Obviously, I'm hoping he's ready for Thursday, but his knee was reinjured, and he couldn't go back in the game."
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