That was it for Garoppolo in this game. The 49ers announced that the quarterback is "questionable" to return due to an ankle injury.
Nick Mullens replaced the 49ers' starting quarterback on the next series with the Seahawks owning a comfortable 30-7 lead through three quarters of play.
Garoppolo finished the game 11-of-16 for 84 yards with no touchdowns and an interception. He missed two games earlier this season after suffering a high-ankle sprain during Week 2.