- Wide receiver Deebo Samuel suffered a hamstring injury.
- Running back Jeff Wilson Jr. suffered an ankle injury.
- Wide receiver Richie James suffered an ankle injury.
"Jeff, we're worried it's a high-ankle sprain," Shanahan said. "That's kind of what it looked like a little bit. I know he's hurting right now. Hopefully, we'll get better news on that tomorrow, but it's not sounding great right now."
Jeremy Fowler of ESPN provided the following update on Wilson.
"Deebo, with a hamstring, you never know," Shanahan continued. "I know it pulled on him on that run, which usually is some time. Hopefully, the severity won't be too bad, and he won't miss too much time.
"Richie, I'm not sure what type of ankle injury it was. They didn't give me any information on that. I know he wasn't able to go back in."
None of the three players returned to the game.
Wilson, 24, sustained his injury in the third quarter while rushing for his third touchdown of the game. He was able to walk gingerly under his own power off the field, was carted to the locker room, and later ruled "out."
Wilson finished the game with 112 rushing yards on 17 carries and two catches for eight yards.
Samuel, 24, exited the game with the 49ers up by 24 points in the fourth quarter. The injury came after the receiver took a one-yard toss from quarterback Jimmy Garoppolo and proceeded to the 14-yard line, setting up a 32-yard field goal and giving San Francisco a 33-6 lead. He too was eventually ruled "out."
Samuel finished the game with five catches for 65 yards and three carries for seven yards.
More San Francisco 49ers News
-
49ers WR jokingly asks for more money after nice Patriots gesture
A gesture by the New England Patriots caught the attention of San Francisco 49ers wide receiver Kendrick Bourne. The Patriots reportedly paid Mack Hollins a $400,000 incentive bonus even though he fell four receptions short of the statistical threshold required to trigger the... -
49ers lose key Kyle Shanahan assistant to NFC West rival Seahawks
The San Francisco 49ers are losing a key member of Kyle Shanahan's coaching staff to a division rival. According to NFL Network insider Tom Pelissero, the Seattle Seahawks are hiring longtime 49ers assistant Brian Fleury as their new offensive coordinator. He replaces Klint... -
Will this 49ers running back escape Kyle Shanahan's doghouse?
Isaac Guerendo flashed intriguing upside during his rookie season in 2024. The San Francisco 49ers running back totaled 420 rushing yards and four touchdowns on 84 carries, averaging an impressive 5.0 yards per attempt. His explosiveness stood out, highlighted by nine runs of... -
49ers restore locker room after Seahawks' Super Bowl LX takeover
The San Francisco 49ers locker room at Levi's Stadium looked a little different during Super Bowl LX — and not in a way 49ers players appreciated. Although the Seattle Seahawks were officially designated as the away team, they were assigned the home locker room and even wore...