Garoppolo missed this past Sunday's game against the New York Giants after suffering an ankle injury the week before against the New York Jets.
The 49ers have just one more practice — a Friday afternoon session — remaining before Sunday's game. Should Garoppolo miss that one too, it seems unlikely the team will play him over the weekend.
Head coach Kyle Shanahan said on Wednesday that Garoppolo would need to practice and show that he can move around well enough to protect himself.
"Anytime you're dealing with an ankle, you might feel all right when you're standing there, but can you move around and get into the awkward positions without hurting yourself?" said Shanahan. "That's really what we'd have to see. It would be tough for us to see that and truly judge that if he didn't get into practice.
"So, hopefully, can get out there for at least one live period, and we have those all the way up until Friday. We've just got to see that he's healthy, but that won't be able to happen if we can't get him in practice."
The 49ers will release their official practice participation and injury report later today.
Other early practice notes from Barrows:
- Cornerbacks K'Waun Williams (hip) and Ahkello Witherspoon (hamstring) were on hand for practice.
- Running back Jerick McKinnon (ribs) was on hand for practice.
- There were no signs of running back Raheem Mostert (knee) or cornerback Emmanuel Moseley (concussion).
More San Francisco 49ers News
-
Brandon Aiyuk blasts 49ers again: 'They mad because they stupid'
Brandon Aiyuk continues to make his frustrations with the San Francisco 49ers public. The wide receiver once again took to Instagram to voice his displeasure with the organization, stating the team regrets the contract extension it awarded him before the 2024 NFL season. "And... -
49ers facing harsh reality as NFL execs label Brandon Aiyuk 'untradeable'
There appears to be no trade market for San Francisco 49ers wide receiver Brandon Aiyuk, despite the team's hope that interest could eventually develop. With rival teams believing the 49ers will ultimately release the disgruntled receiver, there is little incentive to surrender... -
49ers QB Brock Purdy proved unlucky in one category by PFF
San Francisco 49ers quarterback Brock Purdy threw 13 interceptions during his injury-shortened 2025 season, including the playoffs. According to analytics site Pro Football Focus (PFF), only 12 of his passes were deemed turnover-worthy, yet nine of those throws resulted in... -
49ers' roster overhaul reveals a fascinating trend under John Lynch
I have written in the past about what teams should consider when building a roster. Today, I will examine two trends that have emerged recently in 49erland. Trust the Conference In the past five seasons, the following receivers have been All-Pro selections. Ja'Marr...