Also out are quarterback Jimmy Garoppolo, running backs Raheem Mostert and Tevin Coleman, defensive end Dee Ford, and linebacker Dre Greenlaw.
RELATED
Kittle suffered an MCL sprain and bone bruise during the 49ers' Week 1 loss to the Arizona Cardinals and was inactive this past weekend against the New York Jets. He practiced on Wednesday and Thursday, and until Friday, was a possibility to return for Week 3.
Shanahan said he spoke with Kittle before Friday's practice to determine where he is in his recovery. That led to ruling him out against the Giants.
"I thought it was a lot safer to leave him out," Shanahan explained to reporters. "That didn't need to wait another day because of how he sounds today."
More San Francisco 49ers News
-
49ers' Kyle Juszczyk reveals encouraging George Kittle update, praises Mike Evans, minicamp decision
On Saturday, San Francisco 49ers fullback Kyle Juszczyk joined "The Insiders" on NFL Network and discussed where he believes the team currently stands, as well as some of his teammates. How is TE George Kittle coming along in his rehab from a torn Achilles? How does WR Mike... -
Three 49ers named among NFL's top comeback candidates for 2026
The San Francisco 49ers overcame significant adversity last season, losing several key contributors to injuries. Despite those setbacks, the team remained competitive down the stretch and ultimately secured a playoff berth. Bleacher Report's Gary Davenport attempted to predict... -
49ers' Brandon Aiyuk drama: What's really behind the receiver's frustration?
Forty Niner (eventually ex-Forty Niner) wide receiver Brandon Aiyuk has recently taken to social media to express his displeasure with the organization, at times naming the team directly and at other times alluding to the team's management. In one, he called the powers-that-be... -
Writer proposes 49ers trade package for Maxx Crosby
Could the San Francisco 49ers pull off a blockbuster trade of their own after the Los Angeles Rams landed Myles Garrett? With the NFC West arms race heating up, some believe the 49ers should explore a deal for Las Vegas Raiders star pass rusher Maxx Crosby. Bleacher Report's...