Also out are quarterback Jimmy Garoppolo, running backs Raheem Mostert and Tevin Coleman, defensive end Dee Ford, and linebacker Dre Greenlaw.
RELATED
Kittle suffered an MCL sprain and bone bruise during the 49ers' Week 1 loss to the Arizona Cardinals and was inactive this past weekend against the New York Jets. He practiced on Wednesday and Thursday, and until Friday, was a possibility to return for Week 3.
Shanahan said he spoke with Kittle before Friday's practice to determine where he is in his recovery. That led to ruling him out against the Giants.
"I thought it was a lot safer to leave him out," Shanahan explained to reporters. "That didn't need to wait another day because of how he sounds today."
More San Francisco 49ers News
-
Kyle Shanahan shares 49ers injury updates, discusses Keenan Allen, Cowboys matchup
San Francisco 49ers head coach Kyle Shanahan spoke with reporters ahead of Wednesday's practice as the team prepares for its Week 10 matchup against the Dallas Cowboys. Here's everything he said. Transcript provided by the San Francisco 49ers Communications staff. Opening... -
49ers' Keenan Allen impressed with Brock Purdy, Kyle Shanahan, addresses Mike Evans beef
Wide receiver Keenan Allen will participate in his first practice with the San Francisco 49ers on Wednesday, giving him his first opportunity to catch passes from quarterback Brock Purdy as he begins learning head coach Kyle Shanahan's offense. Allen was asked what he's... -
49ers' Kyle Shanahan reveals his reaction to Mac Jones trade interest
Kyle Shanahan confirmed that multiple teams inquired about San Francisco 49ers quarterback Mac Jones ahead of the NFL trade deadline. However, nothing came of those discussions, with the 49ers' reported asking price exceeding what interested teams were willing to pay. Shanahan... -
Kyle Shanahan reveals what Keenan Allen brings to the 49ers after trade
The San Francisco 49ers made a move just hours before Tuesday's NFL trade deadline, acquiring wide receiver Keenan Allen from the Indianapolis Colts. The trade addresses a significant need for the 49ers, whose wide receiver depth has been depleted by injuries. Key...