Maybe that still happens. But the 49ers will need to get back some of the players from their growing injury list.
The defensive line, which is vital to the defense's success, has already taken a significant hit with the losses of two former first-round picks in Nick Bosa and Solomon Thomas. Both saw their seasons end during Week 2 after suffering torn ACLs.
Here is an updated list of the 49ers' current injury situation.
| Player | Pos | Injury | Status |
| Tavon Austin | WR | Knee | IR, out for season |
| Ronald Blair | DE | Torn ACL (2019) | PUP through Week 6 |
| Nick Bosa | DE | Torn ACL | Out for season |
| Tevin Coleman | RB | Knee sprain | Out multiple weeks |
| Dee Ford | DE | Back | Unknown |
| Jimmy Garoppolo | QB | High-ankle sprain | Week-to-week |
| Dre Greenlaw | LB | Thigh contusion | Unknown |
| Tim Harris* | CB | Calf | IR through Week 4 |
| Jalen Hurd | WR | Torn ACL | IR, out for season |
| Richie James Jr. | WR | Hamstring strain | IR through Week 4 |
| D.J. Jones | DT | Ankle | Unknown |
| George Kittle | TE | MCL sprain, bone bruise | Week-to-week |
| Raheem Mostert | RB | MCL sprain | Week-to-week |
| Weston Richburg | C | Torn patellar (2019) | PUP through Week 6 |
| Deebo Samuel | WR | Jones fracture | IR through Week 3 |
| Richard Sherman | CB | Calf strain | IR through Week 4 |
| Jullian Taylor | DL | Torn ACL (2019) | PUP through Week 6 |
| Solomon Thomas | DL | Torn ACL | Out for season |
| Chris Thompson** | WR | Unknown | IR, out for season |
| Jason Verrett | CB | Hamstring strain | day-to-day |
More San Francisco 49ers News
-
49ers X-Factors: 3 Players Who Could Raise the Defense's Ceiling in 2026
Most people start by talking about the stars when they discuss the San Francisco 49ers' defense. Nick Bosa. Fred Warner. Dre Greenlaw. But championship defenses need more than just star players. They come together when talented players step up and help everyone around them... -
Florio: Reporting to 49ers training camp could boost Brandon Aiyuk's leverage
The rift between the San Francisco 49ers and wide receiver Brandon Aiyuk appears significant, with the receiver recently taking multiple public shots at the organization. The 49ers have already voided a portion of the guaranteed money in the four-year, $120 million contract... -
49ers Hall of Fame adds dynasty legend Keena Turner as 34th inductee
The San Francisco 49ers and the York family announced that linebacker Keena Turner will become the 34th inductee into the Edward J. DeBartolo Sr. San Francisco 49ers Hall of Fame. Turner's induction ceremony will take place in San Francisco's Week 6 matchup against the... -
49ers All-Pro George Kittle: Mike Evans was 'cooking everybody' during OTAs
Mike Evans is expected to elevate the San Francisco 49ers offense in 2026, giving quarterback Brock Purdy a big-bodied red-zone weapon—arguably the best of his NFL career. While Evans has not typically participated in organized team activities (OTAs), which are voluntary...