The 49ers beat the Cardinals 36-26 improving to 9-1 on the season.
Garoppolo finished the game with a 75.6 completion percentage, 424 passing yards, four touchdowns, two interceptions, and a passer rating of 115.4.
The other nominees for the FedEx Air Player of the Week are quarterbacks Dak Prescott of the Dallas Cowboys and Kirk Cousins of the Minnesota Vikings.
Samuel caught eight passes from Garoppolo for 134 receiving yards against the Cardinals.
The 49ers' rookie receiver is up against quarterback Kyler Murray of the Arizona Cardinals, running back Josh Jacobs and defensive end Maxx Crosby of the Oakland Raiders, and cornerback Marvell Tell of the Indianapolis Colts.
Fans can vote for Garoppolo below or by clicking here.
Fans can click here to vote for Samuel.
More San Francisco 49ers News
-
49ers QB Brock Purdy named NFC Offensive Player of the Week after 5-TD game
San Francisco 49ers quarterback Brock Purdy has been named the NFC Offensive Player of the Week following his standout Week 16 performance against the Indianapolis Colts. Purdy completed 25 of 34 passes (73.5 percent) for 295 yards and a career-high five touchdown passes,... -
Only one 49ers player leads position group in Pro Bowl voting
The NFL Communications staff released the latest voting results for the 2026 Pro Bowl Games, with the AFC and NFC rosters set to be unveiled Tuesday morning. Among the San Francisco 49ers, only one player currently leads his position group: fullback Kyle Juszczyk. Selections... -
49ers rookie CJ West reflects on first career sack—against Philip Rivers
San Francisco 49ers rookie defensive tackle CJ West tied teammate Alfred Collins for the top Pro Football Focus pass-rush grade of the game, both posting career-high 91.7 marks. Each recorded their first NFL sack in the 49ers' 48-27 win over the Indianapolis Colts, marking the... -
49ers open as slight favorites in Week 18 showdown with Seahawks
There's plenty at stake Saturday night when the San Francisco 49ers host the Seattle Seahawks at Levi's Stadium. The winner not only claims the NFC West crown but also secures the No. 1 seed in the NFC playoffs and home-field advantage. For the 49ers, that top seed would be...