- Safety Adrian Colbert exited the game with a hamstring injury.
- Defensive lineman Damontre Moore suffered a dislocated thumb.
- Cornerback Tim Harris had a groin injury.
- Wide receiver Shawn Poindexter sustained a knee injury.
- Defensive back D.J. Reed had a shoulder injury.
- Linebacker Demetrius Flannigan-Fowles had the wind knocked out of him.
- Safety Jaquiski Tartt was evaluated for a concussion but cleared to return.
The 49ers won the game at Mile High Stadium by a score of 24-15 and will play the Kansas City Chiefs at Arrowhead Stadium on Saturday.
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