Cornerback Richard Sherman (calf) is active and looks to play, and the Niners offense will have running back Matt Breida (ankle) active as well. Rookie wide receiver Dante Pettis (knee) makes his return after suffering his injury on a punt return against the Los Angeles Chargers back in Week 4.
That said, head coach Kyle Shanahan's squad will be down a wide receiver, Pierre Garçon (knee), and will be without starting center Weston Richburg (knee). Here's the full list of San Francisco inactives for their NFC West road contest in Arizona:
- QB Tom Savage
- WR Pierre Garçon
- DB Greg Mabin
- C Weston Richburg
- DT Jullian Taylor
- OT Shon Coleman
- DT D.J. Jones
Garçon was downgraded to OUT earlier this week, so that's not much of a surprise. But Richburg's injury is significant. This will mark the first time in 2018 Richburg has missed a start. The 49ers have two options to replace him at center, Mike Person and second-year pro Erik Magnuson. Person, who has started this year at right guard, also doubles as a center. But if the Niners want to, they can keep him at guard and insert Magnuson in at Richburg's spot.
Offensive guard Joshua Garnett is also active for the contest.
The 49ers and Cardinals kick off on Oct. 28 at 4:25 p.m. ET from University of Phoenix Stadium in Glendale, Arizona.
Written By:
Peter Panacy has been writing about the 49ers since 2011 for outlets like Bleacher Report, Niner Noise, 49ers Webzone, and is occasionally heard as a guest on San Francisco's 95.7 FM The Game and the Niners' flagship station, KNBR 680. Feel free to follow him, or direct any inquiries to his Twitter account.
All articles by Peter Panacy
@PeterPanacy
YouTube Channel
Peter Panacy
Peter Panacy has been writing about the 49ers since 2011 for outlets like Bleacher Report, Niner Noise, 49ers Webzone, and is occasionally heard as a guest on San Francisco's 95.7 FM The Game and the Niners' flagship station, KNBR 680. Feel free to follow him, or direct any inquiries to his Twitter account.
All articles by Peter Panacy
More San Francisco 49ers News
-
Where does 49ers' Mac Jones rank among NFL backup QBs by trade value?
Mac Jones saved the San Francisco 49ers' season in 2025. That wasn't a statement any fan expected to hear before last season began. But it happened. And it's not an overreaction. Starting QB Brock Purdy missed eight games in 2025. And Jones filled in admirably, going 5-3, and... -
Two 49ers named among NFL's most underrated players
Pro Football and Sports Network's (PFSN) Jacob Infante highlighted 12 of the NFL's most underrated players from the 2025 season, and the list included two San Francisco 49ers contributors. Infante utilized PFSN's Impact Scoring metric, which assigns a numerical value to... -
49ers' George Kittle shares update on Week 1 availability amid Achilles recovery
San Francisco 49ers tight end George Kittle suffered a torn Achilles during the Wild Card playoff victory over the Philadelphia Eagles, forcing him to miss the following week's Divisional Round matchup against the Seattle Seahawks. Initially, the injury was viewed as one that... -
49ers' Trent Williams has two-word reaction to Rams landing Myles Garrett
San Francisco 49ers left tackle Trent Williams will be among the players responsible for slowing down star pass rusher Myles Garrett when the team faces the Los Angeles Rams in its Week 1 international matchup in Australia. On Wednesday, the veteran offensive lineman—widely...