Who will be tasked with stopping Mahomes and the Chiefs? The San Francisco 49ers.
No pressure, right?
The 49ers are coming off of a 30-27 victory over the Detroit Lions. While the win improved the team's record to 1-1, not everyone was thrilled by the performance, which saw the Lions nearly come back and steal away the victory.
"A win is a win, but it feels like a loss to me," cornerback Richard Sherman said after the game. "We played like crap down the stretch on defense."
As things stand now, Vegas oddsmakers have the home-team Chiefs listed as anywhere from 6- to 7-point favorites over Sherman and the visiting 49ers, according to various casinos and betting sites.
The spread consensus has the Chiefs as 6.5-point favorites. Those numbers could change as the game draws near. The over/under for Sunday's game is listed at 56 points.
San Francisco came out on top by a score of 22-17 the last time the two teams met — an October 5, 2014 matchup at Levi's Stadium. The Chiefs, however, have won four straight over the 49ers at Arrowhead.
The 49ers and Chiefs kick off at 10:00 a.m. PT (12:00 p.m. CT) on Sunday.