The teams have played 32 contests with the 49ers holding a 17-15 advantage.
San Francisco has won six of the last seven games against the Giants stretching back to the 1991 season.
The teams have also faced each other seven times in the postseason with the 49ers having a 4-3 advantage.
The Giants won the team's last regular season meeting 24-6 in 2005 at Monster Park.
Mike Nolan's father, Dick Nolan played for the New York Giants from 1954-56 and 1958-61.
Nolan also received his first defensive coordinator job from the Giants from 1993-96.
In Nolan's first year as defensive coordinator the team finished fifth in the NFL.
SCHEDULE
10/19
11-12:30 p.m. practice.
Media availability after practice.
Team travels to New York.
10/20
Walk-thru (closed to media).
10/21
10:00 a.m. (PST) kickoff vs. New York Giants.
SAMSUNG 49ERS RADIO NETWORK
The 49ers-Giants game can be heard on the Samsung 49ers Radio Network. Locally, the game can be heard on KNBR 680 AM and KSAN 107.7 FM. Joe Starkey returns to handle the play-by-play. He is joined in the booth by former San Francisco linebacker Gary Plummer, who provides color commentary and game analysis. Rod Brooks will handle sideline duties.
SPANISH RADIO
The San Francisco will broadcast games on two Spanish language stations KIQI Radio 1010 in San Francisco and KATD 990 in Sacramento. Broadcast duties will be held by Spanish sports announcers Fernando Arias and Ambrosio Rico, both from the Bay Area. Arias will be calling play by plays with Rico adding color commentary. Both broadcasters have extensive experience announcing NFL games in Spanish.
TELEVISION
The game will be televised on FOX with a scheduled 10:00 a.m. PST kickoff from New York. Matt Vasgersian and Daryl Johnston will be in the booth. Tony Siragusa will handle sideline duties.
More San Francisco 49ers News
-
49ers preseason schedule: Dates, times, and TV info for all three games
The NFL announced the dates and kickoff times for every preseason game on Wednesday, completing the San Francisco 49ers' 2026 exhibition schedule. The only remaining unknown was the kickoff time for the 49ers' preseason opener against the Tennessee Titans at Levi's Stadium on... -
49ers' Mac Jones has no regrets about his contract decision
Mac Jones could have positioned himself for a sizable payday this offseason had he signed a one-year deal with the San Francisco 49ers instead of the two-year contract he agreed to last year. After spending a season under head coach Kyle Shanahan, however, the veteran... -
Where does 49ers' Mac Jones rank among NFL backup QBs by trade value?
Mac Jones saved the San Francisco 49ers' season in 2025. That wasn't a statement any fan expected to hear before last season began. But it happened. And it's not an overreaction. Starting QB Brock Purdy missed eight games in 2025. And Jones filled in admirably, going 5-3, and... -
USA Today predicts 49ers record for 2026
Last season, the San Francisco 49ers finished with an impressive 12-5 record, despite many injuries to key players. Some injuries, like those to Brock Purdy, George Kittle, and Ricky Pearsall, lasted multiple weeks. But there were more devastating ones, like the season-ending...