| 1st | 2nd | 3rd | 4th | Tot | |
| NO | 14 | 17 | 0 | 10 | 41 |
| SF | 3 | 17 | 3 | 0 | 23 |
Later, with the Saints leading 41-23 and the 49ers driving down the field, Kaepernick fumbled the football following a bad snap and New Orleans recovered to end the San Francisco scoring threat. Another fumble late in the game, this time by Harris, would seal the loss for San Francisco, who went down by the score of 41-23.
| NO | SF | |
| First Downs | 29 | 19 |
| Total Yards | 571 | 486 |
| Passing Yards | 323 | 393 |
| Rushing Yards | 248 | 93 |
| Penalties (Yds) | 4 (40) | 9 (78) |
| Turnovers | 0 | 4 |
| Punts (AVG) | 4 (47) | 2 (43) |
| Time of Pos. | 38:23 | 21:06 |
Kaepernick ended the game with 398 passing yards, his most since passing for 412 on September 8, 2013 against the Green Bay Packers. He had two touchdowns, an interception, and would finish with a 102.3 passer rating. Harris rushed for 59 yards on 10 carries for the 49ers and Patton led the receivers with 106 yards. For the Saints, Brees had 323 yards passing for three touchdowns. Ingram led New Orleans on the ground, rushing for 158 yards and a touchdown. Thomas led the Saints' receivers with 73 yards and two touchdowns.
| 49ers Team Leaders | ||||
| Passing | CP/AT | YDS | TD | INT |
| C. Kaepernick | 24/39 | 398 | 2 | 1 |
| Rushing | CAR | YDS | TD | LG |
| D. Harris | 10 | 59 | 0 | 19 |
| Receiving | REC | YDS | TD | LG |
| Q. Patton | 6 | 106 | 0 | 31 |
Injuries
DE Arik Armstead left the game in the first quarter after aggravating his left shoulder, an injury that has plagued the second-year player since training camp.
OLB Eli Harold went down with an injury in the first quarter of play. He would return to the game in the second quarter.
LB Nick Bellore left the game in the second quarter with what looked to be an arm/shoulder injury. He returned to the game.
FS Eric Reid jogged off of the field with medical staff after he was slow to get up in the fourth quarter.
Notes and Quotes
The 49ers made NFL history on Sunday when they became the first team ever to give up 7-straight 100-yard rushers. The Saints would end up rushing for 248 yards as a team.
| Week | Running Back | Rush Yds | TDs |
| 1 | Todd Gurley, LA | 47 | 0 |
| 2 | Fozzy Whittaker, CAR | 100 | 0 |
| 3 | Christine Michael, SEA | 108 | 2 |
| 4 | Ezekiel Elliott, DAL | 138 | 1 |
| 5 | David Johnson, ARI | 157 | 2 |
| 6 | LeSean McCoy, BUF | 140 | 3 |
| 7 | Jacquizz Rodgers, TB | 154 | 0 |
| 9 | Mark Ingram, NO | 158 | 1 |
The last time the 49ers lost seven straight games was in 2007 when they lost eight in a row under then-head coach Mike Nolan.
QB Colin Kaepernick has surpassed 2,000 career rushing yards. He now has 2,005.
WR Quinton Patton had his first 100-yard receiving game.
The 49ers have given up over 37 points-per-game in their seven-straight losses.
"We're not good enough on the defensive side of the ball to turn the ball over like that," head coach Chip Kelly said of the 49ers running backs following the loss.
Kelly said that there are no plans to make changes to the 49ers defensive coaching staff. He said that the decision for Jim O'Neil, who is normally on the sidelines during games, to go into the booth was O'Neil's call.
Kelly was asked about Arik Armstead's injury and if the team would consider ending his season because of the lingering shoulder issue. Kelly stated that he does not yet know the extent of the injury.
Kaepernick said that he felt that the offense had more rhythm in the loss, but said that they still left a lot out there, particularly in the red zone.
"Complaining about it, worrying about it, aren't going to help you fix it," said Kaepernick regarding the 49ers' 7-game losing streak.
"I thought I could beat the guy with the throw," Kaepernick said of his interception. "I saw him the whole way."
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