Game Day: San Francisco 49ers at Arizona Cardinals

Today, the Arizona Cardinals (2-0) will host the San Francisco 49ers (1-1) at University of Phoenix Stadium in Glendale, Arizona.

The 49ers are coming off of a 43-18 loss against the Pittsburgh Steelers. The Cardinals are coming off of a 48-23 victory against the Chicago Bears.

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Today's game will be the 49ers' first against an NFC West opponent. In 2014, each team won their home match-ups, but it's the 49ers that have won five of the last six meetings between the two teams.

Jim Tomsula has already beaten Arizona during his NFL head coaching career. In 2010, he guided the 49ers to a 38-7 victory in the team's final game of the season has the interim head coach.

QB Colin Kaepernick is looking to build on one of the few positives that the team had against the Steelers last week. He is coming off of his fourth career 300+ yard passing game. He was 33 of 46 for 335 yards, and two touchdowns for a passer rating of 106.7. He paired with WR Torrey Smith for a 75 yard touchdown, the longest of Smith's career. The offensive line, especially the right side, will have to give Kaepernick more time. The Steelers got to him five times last week and won the battle at the line of scrimmage for the majority of the game.

The 49ers defense will look to rebound from a game where they allowed QB Ben Roethlisberger to complete 21 of 27 for 369 yards, and three touchdowns for a passer rating of 155.8. He picked the defensive secondary, one of the team's offseason question marks, apart with the deep ball. They will be facing another tough task as they prepare to go up against Cardinals QB Carson Palmer, who has a passer rating of 124.4 this season.

For the second week in a row, RB Reggie Bush will not make the road trip with his teammates as he recovers from the calf strain that he suffered during week 1.

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Kickoff: Sunday, September 27 at 1:05 PM PT

Television: The game will be televised on FOX (Check 506 Sports to see if it is local)

Bay Area Radio: KGO 810 & The Bone 107.7 (Other radio affiliates)

Spanish Radio: KTRB 860

Australian Radio: Triple M

Last Meeting: 12/28/14, 49ers win 20-17, at SF

All-Time Matchup: 49ers lead series 29-18

Current Streak: Won 1

Betting: The Cardinals are 6.5 point favorites.

NFL Fan Picks: 73% pick the Cardinals to win according to Yahoo! Sports

49ers Fan Picks: Within our Pick 'em Contest, 53% believe the Cardinal will win

49ers Schedule: View full schedule

Cardinals News: Cardinals news at Problitz.com

Follow Game Online: NFL.com's Game Center

Discuss: Niner Talk forum

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Injury Report

Team	Pos	Player	Injury	Status
49ers	TE	Blake Bell	Back	Probable
49ers	G	Alex Boone	Shoulder	Probable
49ers	LB	NaVorro Bowman	Not injury related	Probable
49ers	RB	Reggie Bush	Calf	Out
49ers	WR	Bruce Ellington	Ankle	Questionable
49ers	RB	Carlos Hyde	Quadriceps	Probable
49ers	TE	Vance McDonald	Knee	Questionable
49ers	WR	Torrey Smith	Knee	Probable
Cardinals	S	Deone Bucannon	Groin	Probable
Cardinals	RB	Andre Ellington	Knee	Doubtful
Cardinals	G	Mike Iupati	Knee	Questionable
Cardinals	S	Tony Jefferson	Hamstring	Probable
Cardinals	WR	J.J. Nelson	Shoulder	Out
Cardinals	LB	Alex Okafor	Shoulder	Probable
Cardinals	LB	LaMarr Woodley	Shoulder	Probable

Game Averages (Rank)

49ers		Cardinals
19.0 (24th)	Offense Pts	39.5 (1st)
402.0 (4th)	Offense Yds	363.5 (11th)
231.5 (17th)	Offense Pass	246.0 (13th)
170.5 (1st)	Offense Rush	117.5 (13th)
23.0 (16th)	Defense Pts Allowed	21.0 (11th)
350.5 (16th)	Defense Yds Allowed	371.5 (22nd)
273.0 (26th)	Defense Pass Allowed	290.0 (28th)
77.5 (6th)	Defense Rush Allowed	81.5 (10th)