Gameday: San Francisco 49ers at Cincinnati Bengals

The San Francisco 49ers' stock went from potential contenders to hoping for a playoff spot during their two-game, home losing streak and will now go on the road to challenge the lone undefeated team in the NFL, the Arizona Cardinals, whose stock could not be higher. Here we discuss the odds and analysis from a betting perspective. When: Sunday October 10th, 2021 1:25pm PT (FOX) Where: State Farm Stadium, Glendale, Arizona Line: 49ers +5.5, over/under 50.5 Arizona Cardinals The Arizona Cardinals are coming off of their biggest win of the season after going into the Los Angeles Rams' home as 4-point underdogs and completely smashing LA by the score of 37-20 to emerge on top of the NFC West and the only undefeated team

"I mean, I'm going to do everything I can to be on the field on Sunday," George Kittle told reporters on Friday. "And then, if my body says I can go, I'll be out there." It sounds like we can expect the San Francisco 49ers star tight end to be out there for the team's first divisional matchup of the season. Despite being listed as "questionable" for the game, per multiple reports, Kittle is expected to be on the field at Levi's Stadium this afternoon when the Niners host the Seattle Seahawks. "While officially a game-time decision, SF has optimism that Kittle will be correct," notes Ian Rapoport of NFL

The San Francisco 49ers have released the list of inactive players for their Week 4 matchup at home against the Seattle Seahawks. These players will not suit up for Sunday's game. Inactives: OL Aaron Banks DL Zach Kerr RB Elijah Mitchell CB Josh Norman CB K'Waun Williams The only roster move the 49ers made on Saturday was activating defensive tackle Maurice Hurst from injured reserve. He is active. The team did not activate running back Kerryon Johnson, or any other player, from the practice squad. With Mitchell ruled out due to a shoulder injury, the team will proceed with Trey Sermon, Jacques

4th Quarter GAME ALERT: The Seahawks defeat the 49ers 28-21 after a slow start to reach 2-2 on the season, moving to 3rd in the NFC West, as the 49ers now drop to 2-2. Freddie Swain recovers the onside kick and essentially guarantees a Seattle victory, as the Seahawks just have to kneel multiple times to win this one. TOUCHDOWN ALERT: Trey Lance finds Deebo Samuel for an eight-yard score and rushes up the middle for the two-point conversion to make the score 28-21. The 49ers need an onside kick to have a chance to tie. On 4th & 10 after an almost-touchdown to George Kittle, Trey Lance maneuvers in the pocket and rushes through the middle for 13 yards to the SEA 8 for another redzone