The Arizona Cardinals will host the San Francisco 49ers at State Farm Stadium in Glendale, Arizona, on Sunday, January 5, at 1:25 p.m. PT. The Cardinals are currently favored by 4.5 points.
Each week, 49ers Webzone staff members participate in the NFL Pick 'em contest, predicting the winners of every NFL game. For Week 18, only one of the four participating staff members has picked the 49ers to beat the Cardinals.
As of this post, 55 percent of fans participating in the NFL Pick 'em contest have predicted a Cardinals victory. This highlights the NFC West showdown as one of the more polarizing matchups of Week 18, with opinions divided on whether the 49ers can stage an upset.
Most One-Sided Matchups: Bears at Packers, Browns at Ravens
Among all Week 18 games, the matchups between the Chicago Bears and Green Bay Packers and the Cleveland Browns and Baltimore Ravens are the most one-sided. An overwhelming 100 percent of fans predict victories for the Packers and Ravens.
Most Competitive Matchup: Vikings at Lions
The most anticipated game of the weekend is Sunday's showdown between the Minnesota Vikings and Detroit Lions. The winner will secure the NFC's top seed and home-field advantage throughout the playoffs. Currently, 54 percent of fans predict the Lions will prevail, making this one of the most competitive matchups of Week 18.
Week 18 NFL Matchups
Below is a breakdown of all 16 matchups for the upcoming slate of NFL games.
| Picks | Away | Home | Picks |
|---|---|---|---|
|
0%
|
Browns
|
Ravens
|
100%
|
|
78%
|
Bengals
|
Steelers
|
22%
|
|
13%
|
Panthers
|
Falcons
|
87%
|
|
89%
|
Commanders
|
Cowboys
|
11%
|
|
0%
|
Bears
|
Packers
|
100%
|
|
82%
|
Texans
|
Titans
|
18%
|
|
22%
|
Jaguars
|
Colts
|
78%
|
|
90%
|
Bills
|
Patriots
|
10%
|
|
10%
|
Giants
|
Eagles
|
90%
|
|
1%
|
Saints
|
Buccaneers
|
99%
|
|
39%
|
Chiefs
|
Broncos
|
61%
|
|
92%
|
Chargers
|
Raiders
|
8%
|
|
25%
|
Seahawks
|
Rams
|
75%
|
|
82%
|
Dolphins
|
Jets
|
18%
|
|
45%
|
49ers
|
Cardinals
|
55%
|
|
46%
|
Vikings
|
Lions
|
54%
|