The Buffalo Bills will host the San Francisco 49ers at Highmark Stadium in Orchard Park, New York, on Sunday, December 1, at 5:20 p.m. PT. The Bills are currently six-point favorites.
Each week, 49ers Webzone staff members participate in the NFL Pick 'em contest, predicting the winners of every NFL game. For Week 13, only two of the seven participating staff members have chosen the 49ers to upset the Bills.
Among fans participating in the NFL Pick 'Em contest, 77 percent are backing a Bills victory as of this writing.
Most One-Sided Matchups: Texans and Buccaneers favored
The most lopsided predictions of the upcoming slate of Week 13 games have a staggering 94 percent of fans believing the Houston Texans beating the Jacksonville Jaguars and the Tampa Bay Buccaneers beating the Carolina Panthers.
Most Competitive Matchup: Steelers at Bengals
The closest predictions of the week involve Sunday's showdown between the Pittsburgh Steelers and Cincinnati Bengals, with 60 percent selecting the Bengals to come out on top.
Week 13 NFL Matchups
Below is a breakdown of all 12 matchups for the upcoming slate of NFL games.
| Picks | Away | Home | Picks |
|---|---|---|---|
|
81%
|
Chargers
|
Falcons
|
19%
|
|
40%
|
Steelers
|
Bengals
|
60%
|
|
7%
|
Cardinals
|
Vikings
|
93%
|
|
76%
|
Colts
|
Patriots
|
24%
|
|
67%
|
Seahawks
|
Jets
|
33%
|
|
7%
|
Titans
|
Commanders
|
93%
|
|
94%
|
Texans
|
Jaguars
|
6%
|
|
73%
|
Rams
|
Saints
|
27%
|
|
94%
|
Buccaneers
|
Panthers
|
6%
|
|
29%
|
Eagles
|
Ravens
|
71%
|
|
23%
|
49ers
|
Bills
|
77%
|
|
13%
|
Browns
|
Broncos
|
87%
|