The San Francisco 49ers are preparing for their Week 6 contest against the Los Angeles Rams on Sunday at the Los Angeles Memorial Coliseum in Los Angeles, California.

The 49ers are already without starting left tackle Joe Staley, and the anchor on the other side of the offensive line, Mike McGlinchey, was nowhere to be seen at the start of Wednesday's practice.

Head coach Kyle Shanahan revealed after practice that McGlinchey will undergo arthroscopic surgery on his left knee and will miss four to six weeks. Daniel Brunskill will start at right tackle in his place.

RELATED 49ers' starting right tackle, Mike McGlinchey, out 4 to 6 weeks with knee injury

The team will also be without Kyle Juszczyk for about a month or more. The Pro Bowl fullback suffered an MCL sprain on Monday night against the Cleveland Browns and will also miss four to six weeks.

Below are Wednesday's practice participation reports for both the 49ers and Rams, which were provided by the 49ers Communications staff.

San Francisco 49ers Wednesday Practice

Did Not Participate In Practice
FB Kyle Juszczyk (knee), T Mike McGlinchey (knee), T Joe Staley (fibula), CB Ahkello Witherspoon (foot)

Limited Participation in Practice
DE Dee Ford (quadricep)

Los Angeles Rams Wednesday Practice

Did Not Participate In Practice
RB Todd Gurley (quadricep), LB Clay Matthews (jaw), LB Natrez Patrick (hamstring), CB Aqib Talib (ribs)

Limited Participation in Practice
WR Brandin Cooks (concussion), LB Bryce Hager (shoulder), S Taylor Rapp (ankle)