The 49ers enter the 2017 offseason with a new (soon-to-be-announced) head coach, a new general manager, and a depleted roster in need of an overhaul.
The NFC West team with the best odds of winning the Super Bowl are the Seattle Seahawks at 16-to-1. The Arizona Cardinals come in second at 33-to-1, followed by the Los Angeles Rams, which opened at 75-to-1.
Below are the opening odds by Bovada for all 32 NFL teams.
| Super Bowl LII Odds | |
| New England Patriots | 19-4 |
| Dallas Cowboys | 9-1 |
| Green Bay Packers | 10-1 |
| Pittsburgh Steelers | 10-1 |
| Atlanta Falcons | 14-1 |
| Denver Broncos | 16-1 |
| Minnesota Vikings | 16-1 |
| Oakland Raiders | 16-1 |
| Seattle Seahawks | 16-1 |
| Carolina Panthers | 25-1 |
| Indianapolis Colts | 25-1 |
| Kansas City Chiefs | 25-1 |
| New York Giants | 25-1 |
| Arizona Cardinals | 33-1 |
| Tampa Bay Buccaneers | 33-1 |
| Baltimore Ravens | 40-1 |
| Detroit Lions | 40-1 |
| Houston Texans | 40-1 |
| Cincinnati Bengals | 50-1 |
| Miami Dolphins | 50-1 |
| New Orleans Saints | 50-1 |
| Philadelphia Eagles | 50-1 |
| Tennessee Titans | 50-1 |
| Washington Redskins | 50-1 |
| Buffalo Bills | 66-1 |
| Jacksonville Jaguars | 66-1 |
| Los Angeles Chargers | 66-1 |
| Los Angeles Rams | 75-1 |
| New York Jets | 75-1 |
| Chicago Bears | 100-1 |
| Cleveland Browns | 150-1 |
| San Francisco 49ers | 150-1 |