The Arizona Cardinals currently hold a 38-7 lead over the San Francisco 49ers. QB Colin Kaepernick is having the first four-interception game of his career, including two returned for touchdowns during the 49ers' first two drives today.

FS Tyrann Mathieu (2), CB Justin Bethel (1), and CB Jerraud Powers (1) are responsible for the Cardinals' interceptions today.

Kaepernick had a three-interception game last season against the Chicago Bears. He is also responsible for the 49ers' only touchdown of the game where he had a 12-yard run into the end zone.

Kaepernick is the first 49ers quarterback to throw four interceptions in a game since Trent Dilfer did it against the Carolina Panthers in 2007.