SEATTLE -- The San Francisco 49ers have lost standout left guard Mike Iupati.Iupati injured his left ankle on a 1-yard touchdown run by 49ers' fullback Anthony Dixon to give San Francisco a 10-0 lead over the Seattle Seahawks in the second quarter of the NFC title game. Iupati had to be helped off the field and couldn't put weight on his ankle. He was carted off the field.He was replaced by Adam Snyder, who started four games this season and played well when Iupati suffered a sprained MCL Nov.