The San Francisco 49ers go into Week 16 -- in which they can clinch their third playoff berth in three seasons with Jim Harbaugh as coach -- with their 53-man roster in fairly good health.Left guard Mike Iupati and receiver Mario Manningham are likely the biggest question marks.Like last week, Iupati was limited all week. He has missed the past four games with a sprained knee. Harbaugh told reporters Saturday that Iupati had a productive week, but no decision has been made whether he will play Monday night against Atlanta.