San Francisco 49ers offensive tackle Joe Staley was injured during the 49ers' game against the St. Louis Rams. He was on the sideline being examined by medical staff. When he tried to stand up and put pressure on his leg, he was in noticeable pain. Staley is unlikely to return to the game.

The injury occurred in the first quarter of the game. Staley, a two-time Pro Bowler, was drafted in the first round of the 2007 NFL Draft by the 49ers.

The injury could be big for the 49ers, who are already missing guard Mike Iupati due to injury.