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LONDON -- The San Francisco 49ers have won four straight games and are one of the hottest teams in the NFL. The Jacksonville Jaguars are 0-7, and some pundits think the hapless outfit could pull a reverse table run.The 49ers are two-plus touchdown favorites to win this mismatch at Wembley Stadium.The mismatch looks staggering. The 49ers have scored, at least, 31 points in four straight games. Jacksonville had lost eight straight games by 10 points or more.