SANTA CLARA, Calif. – The two biggest injury concerns for the San Francisco 49ers -- inside linebacker Patrick Willis and defensive tackle Ray McDonald -- are listed as questionable to face the visiting Arizona Cardinals on Sunday.Barring setbacks, both should be able to play but will probably be game-time decisions.Willis has missed the past two games with a groin injury but made progress this week. McDonald, who suffered a bicep injury Sunday against Houston, practiced for the first time this week on Friday.