This afternoon, the 49ers will host the Indianapolis Colts at Candlestick Park in San Francisco. The two teams have not faced each other since November of 2009 when the Colts beat the 49ers 18-14 in Indianapolis.

The Colts made headlines this week with a blockbuster trade that sent Browns running back Trent Richardson to Indianapolis for the Colts' 2014 first-round pick. Colts head coach Chuck Pagano said Thursday that Richardson will play against the 49ers. When asked how much he would play, Pagano said "As much as he can handle."


One 49ers player also made headlines this week. Star linebacker Aldon Smith was arrested Friday morning on suspicion of driving under the influence and marijuana possession. Smith had also been arrested for DUI in Miami Beach on Jan. 28, 2012. On June 30, 2012, he suffered stab wounds at a party at his house outside San Jose. 49ers head coach Jim Harbaugh said that Smith will play today against the Colts. Smith has 3.5 sacks this season.

The matchup between the 49ers and Colts is a reunion for Jim Harbaugh and his former Stanford star quarterback Andrew Luck. This will be the first time the 49ers coaching staff has faced Luck in the NFL. Luck was drafted with the first overall pick in the 2012 NFL Draft.

Another potential matchup could happen between brothers. Vernon Davis, who is listed as questionable with a hamstring injury, may not play in the game. However, if he does, his younger brother will be on the opposing defense. Vontae Davis plays cornerback for the Colts.

Last week, the 49ers (1-1) were beat 29-3 by the Seattle Seahawks. The Colts (1-1) were beat 24-20 by the Miami Dolphins.

For the 49ers, RB LaMichael James (knee), TE Vernon Davis (hamstring), DT Ray McDonald (ankles) and S Eric Reid (concussion) are listed as questionable. DT Justin Smith (shoulder), LB NaVorro Bowman (wrist), LB Aldon Smith (back), G Mike Iupati (shoulder) and QB Colin Kaepernick (foot) are listed as probable.

For the Colts, TE Dwayne Allen (hip) was placed on IR. S LaRon Landry (ankle) is out. LB Pat Angerer (knee) is listed as doubtful. S Antoine Bethea (toe) and C Samson Satele (elbow) are listed as questionable. WR T.Y. Hilton (groin), WR David Reed (quadricep), LB Kavell Conner (ankle), WR Darrius Heyward-Bey (ribs) and WR Reggie Wayne (shoulder) are listed as probable.

The game kicks off at 1:25 PM PT and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.

The game will be televised on CBS.

Within Yahoo! Sports, a popular mobile phone scores application, 83% of fans believe that the 49ers will win this game.

Within our Pick 'em contest, 99% of fans believe that the 49ers will win this game.

You can follow the game live on NFL.com's Game Center.

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Article photo by Denny Medley of USA Today Sports