The San Francisco 49ers return home to face the St. Louis Rams in a matchup of NFC West foes. The 49ers hold the edge in the all-time series 62-61-2, including wins in 7 of the last 8 meetings.

Quarterback Alex Smith earned NFC Offensive Player of the Week honors in the 49ers' 24-3 victory at Arizona on Monday Night Football. Smith completed 18 of 19 pass attempts for 232 yards, 3 touchdowns and QB rating of 157.1. Smith set the single-game NFL record with a 94.7 completion percentage with a minimum of 15 attempts. Wide receiver Michael Crabtree led the way with 5 receptions for 72 yards and 2 touchdowns.

The 49ers defense held the Cardinals to just 7 yards rushing on 9 carries, tying the franchise record for fewest rushing yards allowed in a game.

The Rams (3-5) are coming off of a 45-7 loss to the New England Patriots.

The game kicks off at 1:25 PM PT and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.

The game will be televised on FOX. The radio broadcast of the game will be on KGO 810 AM and The Bone 107.7 FM.

Within our 2012 NFL Pick 'Em Contest, 99% of fans fans believe that the 49ers will win this game.

Within Sportstacular, a popular mobile phone scores application, 93% of fans believe that the 49ers will win this game.

You can follow the game live on NFL.com's Game Center.

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