Adam Schefter of the NFL Network is reporting that the word around San Francisco is that Staley will likely start at right tackle and has seemingly won the job from Kwame Harris.
Of course, this is still speculation at this point and the team has not made a formal announcement regarding this.
Matt Maiocco of the Press Democrat had this to say in his blog, Instant 49ers:
...the team is going to wait until they see how things go Saturday night when Staley and Harris both play against the Bears' No. 1 defense. (However, I'm in agreement that Staley is the favorite at this point.)