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Which RB to start? PPR league

I have Mendenhall and Parker, which one of those two against Denver or do i start Jamal Charles from KC against Jacksonville seeing as LJ is out.

Help me out guys this is for sole posession of first place.
I would absolutley go with Charles over either of the Pitt rb's. Jacksonville did not look very good against Chris Johnson and I would think that Denver would do a very good job stopping the run at home.
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