It can really take away from the fun of the league if you play in a wacky setup. I played 2 QBs once, and it was an awful league. Anyone with two good QBs was untouchable. The more realistic you can make the lineup, the more fun it will be for the league. Plus, if you create roster positions that help balance things out and give everyone a good shot at winning, the league will be more competitive all season long.