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As expected, RB Carlos Hyde will miss his sixth straight game for the San Francisco 49ers. He has been attempting to recover from a stress fracture in his foot. TE Vance McDonald, who suffered a concussion against the Chicago Bears on Sunday, has also been ruled out. Rookie TE Blake Bell is the only other tight end on the active roster. However, the team could promote someone from the practice squad on Saturday.
LB Michael Wilhoite who reportedly has a high ankle sprain, will miss Sunday's game. He had been nursing an ankle injury before leaving the game against the Bears.
CB Tramaine Brock and WR Torrey Smith, the latter of which had the game-winning touchdown in overtime against Chicago, also appeared on the injury report. Both are listed as questionable. Brock was limited in Friday's practice. 49ers head coach Jim Tomsula didn't appear to be too concerned about Smith on Friday.
San Francisco 49ers
Out: RB Carlos Hyde (foot), TE Vance McDonald (concussion), LB Michael Wilhoite (ankle)
Questionable: CB Tramaine Brock (foot), LB Aaron Lynch (concussion), WR Torrey Smith (back, toe)
Probable: DT Arik Armstead (shoulder), WR Anquan Boldin (hamstring), G Alex Boone (knee), LB NaVorro Bowman (shoulder, finger), DT Quinton Dial (shoulder), RB Kendall Gaskins (hamstring), LB Eli Harold (shoulder), C Marcus Martin (ankle), T Erik Pears (knee), NT Mike Purcell (shoulder), T Joe Staley (knee), S Jaquiski Tartt (ankle), G Andrew Tiller (knee)
Out: CB Justin Gilbert (concussion), CB Joe Haden (concussion), WR Andrew Hawkins (concussion)
Questionable: TE Gary Barnidge (ankle), WR Travis Benjamin (shoulder), WR Taylor Gabriel (concussion), WR Brian Hartline (hip), WR Marlon Moore (ribs)
Probable: G Cameron Erving (ankle), QB Johnny Manziel (right elbow)