Today, the Arizona Cardinals (2-0) will host the San Francisco 49ers (1-1) at University of Phoenix Stadium in Glendale, Arizona.

The 49ers are coming off of a 43-18 loss against the Pittsburgh Steelers. The Cardinals are coming off of a 48-23 victory against the Chicago Bears.


Today's game will be the 49ers' first against an NFC West opponent. In 2014, each team won their home match-ups, but it's the 49ers that have won five of the last six meetings between the two teams.

Jim Tomsula has already beaten Arizona during his NFL head coaching career. In 2010, he guided the 49ers to a 38-7 victory in the team's final game of the season has the interim head coach.

QB Colin Kaepernick is looking to build on one of the few positives that the team had against the Steelers last week. He is coming off of his fourth career 300+ yard passing game. He was 33 of 46 for 335 yards, and two touchdowns for a passer rating of 106.7. He paired with WR Torrey Smith for a 75 yard touchdown, the longest of Smith's career. The offensive line, especially the right side, will have to give Kaepernick more time. The Steelers got to him five times last week and won the battle at the line of scrimmage for the majority of the game.

The 49ers defense will look to rebound from a game where they allowed QB Ben Roethlisberger to complete 21 of 27 for 369 yards, and three touchdowns for a passer rating of 155.8. He picked the defensive secondary, one of the team's offseason question marks, apart with the deep ball. They will be facing another tough task as they prepare to go up against Cardinals QB Carson Palmer, who has a passer rating of 124.4 this season.

For the second week in a row, RB Reggie Bush will not make the road trip with his teammates as he recovers from the calf strain that he suffered during week 1.


Kickoff: Sunday, September 27 at 1:05 PM PT

Television: The game will be televised on FOX (Check 506 Sports to see if it is local)

Bay Area Radio: KGO 810 & The Bone 107.7 (Other radio affiliates)

Spanish Radio: KTRB 860

Australian Radio: Triple M

Last Meeting: 12/28/14, 49ers win 20-17, at SF

All-Time Matchup: 49ers lead series 29-18

Current Streak: Won 1

Betting: The Cardinals are 6.5 point favorites.

NFL Fan Picks: 73% pick the Cardinals to win according to Yahoo! Sports

49ers Fan Picks: Within our Pick 'em Contest, 53% believe the Cardinal will win

49ers Schedule: View full schedule

Cardinals News: Cardinals news at Problitz.com

Follow Game Online: NFL.com's Game Center

Discuss: Niner Talk forum

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Injury Report

TeamPosPlayerInjuryStatus
49ers TE Blake Bell Back Probable
49ers G Alex Boone Shoulder Probable
49ers LB NaVorro Bowman Not injury related Probable
49ers RB Reggie Bush Calf Out
49ers WR Bruce Ellington Ankle Questionable
49ers RB Carlos Hyde Quadriceps Probable
49ers TE Vance McDonald Knee Questionable
49ers WR Torrey Smith Knee Probable
Cardinals S Deone Bucannon Groin Probable
Cardinals RB Andre Ellington Knee Doubtful
Cardinals G Mike Iupati Knee Questionable
Cardinals S Tony Jefferson Hamstring Probable
Cardinals WR J.J. Nelson Shoulder Out
Cardinals LB Alex Okafor Shoulder Probable
Cardinals LB LaMarr Woodley Shoulder Probable

Game Averages (Rank)

49ers Cardinals
19.0 (24th)
Offense Pts
39.5 (1st)
402.0 (4th)
Offense Yds
363.5 (11th)
231.5 (17th)
Offense Pass
246.0 (13th)
170.5 (1st)
Offense Rush
117.5 (13th)
23.0 (16th)
Defense Pts Allowed
21.0 (11th)
350.5 (16th)
Defense Yds Allowed
371.5 (22nd)
273.0 (26th)
Defense Pass Allowed
290.0 (28th)
77.5 (6th)
Defense Rush Allowed
81.5 (10th)

Game Articles

49ers could face a big problem in Cardinals' Calais Campbell
The Mercury News

49ers' offensive line will be sternly tested again
San Francisco Chronicle

Preview: 49ers vs. Cardinals
The Mercury News

Game Preview: Five Things to Watch When the 49ers Visit the Cardinals
49ers.com

49ers will keep it close vs. Arizona, but can they win?
Press Democrat

49ers game at Arizona Cardinals at a glance
Sacramento Bee

After failed test, 49ers have chance to rebound in Arizona
San Francisco Chronicle

No Bruce Ellington, Vance McDonald today for 49ers
Sacramento Bee