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Kicking off 2012, the 12-3 San Francisco 49ers will travel to face the 2-13 division rival St. Louis Rams at the Edward Jones Dome in St. Louis, Missouri.
The 49ers are coming off of a 19-17 win over the Seattle Seahawks while the Rams are coming off of a 27-0 loss to the Pittsburgh Steelers.
A 49ers victory would clinch a first round bye in the playoffs for San Francisco.
The game kicks off at 10:00 AM and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be televised on FOX.
In the 49erswebzone.com Pick 'Em Contest, 99% of 49ers fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores application, 92% of fans believe that the 49ers will win this game.
You can follow the game live on NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.