The following is a breakdown of the teams that the San Francisco 49ers will face during the 2011 regular-season. However, exact dates and times will not be released until April.

Home: Arizona Cardinals, St. Louis Rams, Seattle Seahawks, Dallas Cowboys, New York Giants, Tampa Bay Buccaneers, Cleveland Browns, Pittsburgh Steelers

Away: Arizona Cardinals, St. Louis Rams, Seattle Seahawks, Philadelphia Eagles, Washington Redskins, Detroit Lions, Baltimore Ravens, Cincinnati Bengals