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Coming off an embarrassing shutout at home against the Buccaneers, the San Francisco 49ers (3-7) will travel to Glendale, Arizona to face the Cardinals (3-7) at the University of Phoenix Stadium for a Monday Night Football showdown.
The game kicks off at 5:30 pm and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be aired on ESPN.
Within our NFL Pick 'em Contest, 71% of fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores app, 60% of fans believe that the 49ers will win this game.
You can follow the game live on NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.